Histaminergic Angioedema

Angioedema is frequently categorized into:

- histamine-mediated disease
- bradykinin-mediated disease

It is critical to determine the underlying mediator of symptoms as it directs treatment.

Histaminergic angioedema is the most frequent cause of angioedema. It is classified as:

- acute (lasting less than 6 weeks)
- chronic (symptoms for longer than 6 weeks)

It is further classified into angioedema presenting with or without urticaria.

Mast cells and basophils are central to the underlying pathophysiology of histamine-mediated angioedema.

The underlying treatments of histamine-mediated angioedema are:

- antihistamines
- corticosteroids
- epinephrine

References:

Histaminergic Angioedema http://buff.ly/2ryJ5dn

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